A method and apparatus provide interference mitigation in a heterogeneous network using beamforming. In the method, a macro Mobile Station (MS) receives a broadcast message including a Precoding Matrix Index (PMI) set restricted in a macro cell, measures a Signal-to-Interference plus Noise Ratio (SINR) and a channel power from an adjacent femto Base Station (BS) and calculates a PMI, determines whether to request a dedicated frequency resource for a macro MS on the basis of the measured SINR, the channel power from the adjacent femto BS, and the calculated PMI, and requests the dedicated frequency resource for the macro MS from a macro BS.