A method of handover in a wireless communication system is disclosed. A method of handover of a mobile station in a wireless communication system with femtocells comprises transmitting a control message including at least one among information of first femtocell base station detected through initial scanning and location information of the mobile station to a base station; receiving information of one or more second femtocell base stations to which the mobile station is accessible, wherein the second femtocell base stations are searched based on the control message from the base station; and performing a handover to one of the second femtocell base stations.