Embodiments of the invention can provide systems and methods for real-time monitoring and analysis of prescription claim rejections. In one embodiment, a transaction performance monitoring system for facilitating real-time monitoring of the rejection of claims can be provided. The transaction performance monitoring system can include a transaction performance monitoring application operable to receive a plurality of claims associated with at least one dispenser, wherein each of the claims relates to at least one prescription and at least one payor. In addition, a transaction performance monitoring application operable to, in real-time, identify rejected claims and associated causes of the rejected claims. Furthermore, a transaction performance monitoring system can include a network operable to communicate the plurality of claims between the at least one dispenser and the at least one payor.