An adjustable knife for a pouch machine is selectively provided with changeable knife hub sets each including a major and minor knife hub with respective major and minor axes. The hub sets have respectively differing diameters or different spacing between the respective major and minor axes to handle a variety of pouch sizes where a filler wheel alternately first fills and seals pouches in a train. A gear linkage including a four gear anti-lash arrangement with a movable gear accommodates variation in distance between hubs of different sets. A method of using the knife is also described.