The present technology provides a mandibular repositioning device (MRD) which may be self titratable. The MRD may be repositioned relative to the maxilla, e.g., the mandible may be brought, via the device, to a position forward of a neutral resting and/or bite position. The MRD allows for adjusting the maintained forward position by simply biting-down to preserve the desired degree of mandibular advancement. The present technology also allows for movement of the mandible in a lateral direction. The lateral movement is allowed for any forward longitudinal positioning of the mandible. The MRD may use a plurality of components that are coupled together and allow for lateral and longitudinal motion between each other. The present technology may be used in MRDs which may be self-fitted, typically by immersing the device in hot water and then biting into the device, making an impression of the teeth in the softened thermoplastic polymer. It may also be applied to MRDs that do not require any fitting to the teeth and to devices that are custom-fabricated by dental labs.