Invention Grant
US08632803B2 System for delivery of protein in insoluble fibrillar or aggregate form
有权
用于递送不溶性纤维或聚集体形式的蛋白质的系统
- Patent Title: System for delivery of protein in insoluble fibrillar or aggregate form
- Patent Title (中): 用于递送不溶性纤维或聚集体形式的蛋白质的系统
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Application No.: US12920096Application Date: 2009-02-18
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Publication No.: US08632803B2Publication Date: 2014-01-21
- Inventor: Yaron Dekel , Rimona Margalit
- Applicant: Yaron Dekel , Rimona Margalit
- Applicant Address: IL Tel Aviv
- Assignee: Ramot At Tel-Aviv University Ltd.
- Current Assignee: Ramot At Tel-Aviv University Ltd.
- Current Assignee Address: IL Tel Aviv
- Agency: Browdy and Neimark, PLLC
- International Application: PCT/US2009/034388 WO 20090218
- International Announcement: WO2009/108554 WO 20090903
- Main IPC: A61K9/127
- IPC: A61K9/127 ; A61K9/14 ; A61K38/28 ; A61P3/10
Abstract:
A pharmaceutical composition containing a therapeutic protein which is particularly amenable to oral administration by providing stability in the gastrointestinal tract. Insoluble fibrils or aggregates of the therapeutic protein in the pharmaceutical composition are encapsulated in a lipidated glycosaminoglycan particle, coated with a multi-layer of lipids and lipid-glycosaminoglycan conjugates, or present as unencapsulated and uncoated insoluble fibrils or aggregates.
Public/Granted literature
- US20110008422A1 SYSTEM FOR DELIVERY OF PROTEIN IN INSOLUBLE FIBRILLAR OR AGGREGATE FORM Public/Granted day:2011-01-13
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