A therapeutic composition is described comprising a particulate dispersion of a hydrocolloid in a low water activity anti-microbial matrix. The composition may also contain any or all of a sequestrant, excipient, carrier and surfactant. The hydrocolloid may be naturally occurring, semisynthetic or synthetic. The invention extends to a method of producing a therapeutic composition. The composition is prepared by mixing a low water activity anti-microbial matrix with hydrocolloid particles at a temperature that will not cause degradation of the matrix. The method may also include the addition of other components such as excipients, sequestrants, carriers and surfactants and other agents. The invention extends to methods for treating a human or animal subject by applying or administering the composition to the subject subject in a therapeutically effective dose.