Invention Grant
- Patent Title: Triazole compounds useful as protein kinase inhibitors
- Patent Title (中): 可用作蛋白激酶抑制剂的三唑化合物
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Application No.: US13094183Application Date: 2011-04-26
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Publication No.: US08633210B2Publication Date: 2014-01-21
- Inventor: Jean-Damien Charrier , Pan Li , Ronald Knegtel , Julian Marian Charles Golec , David Bebbington , Hayley Marie Binch
- Applicant: Jean-Damien Charrier , Pan Li , Ronald Knegtel , Julian Marian Charles Golec , David Bebbington , Hayley Marie Binch
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agent Rory C. Stewart
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/517 ; C07D401/00 ; C07D403/00 ; C07D413/00 ; C07D417/00 ; C07D419/00

Abstract:
This invention describes novel triazole compounds of formula IX: wherein Z1 is nitrogen or CR9 and Z2 is nitrogen or CH, provided that at least one of Z1 and Z2 is nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from —R1; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or Rx and Ry are taken together with their intervening atoms to form a fused ring; R1, R3, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.
Public/Granted literature
- US20120071657A1 TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS Public/Granted day:2012-03-22
Information query
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