Invention Grant
- Patent Title: Oligonucleotide derivative comprising an aromatic compound
- Patent Title (中): 包含芳族化合物的寡核苷酸衍生物
-
Application No.: US13514547Application Date: 2010-12-08
-
Publication No.: US08633304B2Publication Date: 2014-01-21
- Inventor: Yukio Kitade , Yoshiaki Kitamura
- Applicant: Yukio Kitade , Yoshiaki Kitamura
- Applicant Address: JP Gifu-Shi
- Assignee: Gifu University
- Current Assignee: Gifu University
- Current Assignee Address: JP Gifu-Shi
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2009-278456 20091208
- International Application: PCT/JP2010/072020 WO 20101208
- International Announcement: WO2011/071078 WO 20110616
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04

Abstract:
The present invention provides an oligonucleotide derivative that enables to easily synthesize an oligonucleotide derivative chemically modified at the 3′-end with two moieties each having a benzene or pyridine structure with a few steps, an aromatic compound serving as a precursor for preparing the modification carrier for synthesizing oligonucleotide derivative, and the oligonucleotide derivative and the oligonucleotide construct using the same, that is chemically modified at the 3′-end with two moieties each having a benzene or pyridine structure, and has good permeability through a cell membrane and excellent nuclease resistance. The modification carrier for synthesizing oligonucleotide derivative, comprising a unit and a carrier carrying the unit directly or via a linker, wherein the unit is represented by the formula (a): wherein, R1 to R6 each independently represent hydrogen or a substituent other than hydrogen; Z1 and Z2 each independently represent CH or nitrogen; and X represents oxygen or sulfur.
Public/Granted literature
Information query