In an imaging system having a number of subsystems and a control device that controls the subsystems in a coordinated manner to implement a measurement sequence and an operating method therefor, sequence control data that define different functional sub-sequences of the measurement sequence are transmitted to the control device. Different active volumes are associated with the functional sub-sequences. In addition to the sequence control data, active volume position data are provided to the control device that define bearing and extent of the active volumes associated with the different functional sub-sequences. Control signals to implement the measurement sequence for the different subsystems are generated automatically by the control device based on the sequence control data and the active volume position data so that the individual functional sub-sequences are locally optimized at least with regard to a sub-region of their associated active volume.