A method for processing a Channel State Information Reference Signal (CSI-RS) in a wireless communication system based on a multiple access scheme is provided. The CSI-RS transmission method defines a plurality of CSI-RS patterns, assigns the CSI-RS patterns to individual cells, uses the CSI-RSs alternately per Physical Resource Block (PRB) so as to utilize the transmission powers of all antenna ports for transmitting CSI-RSs, transmits Coordinated Multi Point (CoMP) CSI-RSs and non-CoMP CSI-RSs separately, and mutes specific resources in association with the CSI-RS pattern of adjacent cells.