A regional symmetric and interlocked traffic light control method includes: defining a first preferred point in a desired metropolitan area; determining a first axial average vehicle speed and a first axial preferred allowed travel time period for the first axial streets and a second axial average vehicle speed and a second axial preferred allowed travel time period for the second axial streets; obtaining a first vehicle travel distance and a second vehicle travel distance; determining a first control region according to the first preferred point, the first vehicle travel distance and the second vehicle travel distance; defining a second preferred point and a third preferred point adjacent to the first control region; controlling a plurality of traffic lights in the two adjacent control regions to respectively display green and red lights on the same axial streets in accordance with a preferred allowed travel time period and linking the traffic lights in said control regions by serializing. Therefore, a vehicle can pass through a plurality of adjacent control regions in accordance in its cruising speed and the traveling efficiency of the vehicle can be improved.