Invention Grant
US08635031B2 Methods for identifying drug targets based on genomic sequence data
有权
基于基因组序列数据鉴定药物靶标的方法
- Patent Title: Methods for identifying drug targets based on genomic sequence data
- Patent Title (中): 基于基因组序列数据鉴定药物靶标的方法
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Application No.: US11980199Application Date: 2007-10-29
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Publication No.: US08635031B2Publication Date: 2014-01-21
- Inventor: Bernhard Palsson
- Applicant: Bernhard Palsson
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Jones Day
- Main IPC: G01N31/00
- IPC: G01N31/00 ; G01N33/50 ; G01N33/48 ; G06F7/60 ; G06F19/12
Abstract:
This invention provides a computational approach to identifying potential antibacterial drug targets based on a genomic sequence and its annotation. Starting from a fully sequenced genome, open reading frame assignments are made which determine the metabolic genotype for the organism. The metabolic genotype, and more specifically its stoichiometric matrix, are analyzed using flux balance analysis to assess the effects of genetic deletions on the fitness of the organism and its ability to produce essential biomolecules required for growth.
Public/Granted literature
- US20080270096A1 Methods for identifying drug targets based on genomic sequence data Public/Granted day:2008-10-30
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