A structural reinforcing panel system for reinforcing a structure against lateral or shear and uplift loads. The system includes a structural reinforcing panel which is installed between the studs in a wall of the structure. The panel is connected to the foundation of the structure and the sill or header. Two or more panels may be connected together at a corner, within a wall, ceiling or floor. The roof rafters of the structure may be attached to a top plate bracket mounted to the sill plate, which may also be connected to one or more structural reinforcing panels, provides uplift load support for the structure. For structures built on piers, a pier mount bracket provides a linkage to one or more structural reinforcing panels.