Invention Grant
US08636997B2 Method of treating multiple sclerosis with interferon-beta and an IL-2R antagonist
有权
用干扰素-β和IL-2R拮抗剂治疗多发性硬化症的方法
- Patent Title: Method of treating multiple sclerosis with interferon-beta and an IL-2R antagonist
- Patent Title (中): 用干扰素-β和IL-2R拮抗剂治疗多发性硬化症的方法
-
Application No.: US13612763Application Date: 2012-09-12
-
Publication No.: US08636997B2Publication Date: 2014-01-28
- Inventor: Roland Martin , Henry McFarland , Bibiana Bielekova , Thomas Waldmann
- Applicant: Roland Martin , Henry McFarland , Bibiana Bielekova , Thomas Waldmann
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Dechert LLP
- Main IPC: A61K38/21
- IPC: A61K38/21 ; A61K39/395 ; C07K14/565 ; C07K16/28
Abstract:
Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease is multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease.
Public/Granted literature
- US20130095069A1 METHOD OF TREATING AUTOIMMUNE DISEASES WITH INTERFERON-BETA AND IL-2R ANTAGONIST Public/Granted day:2013-04-18
Information query
IPC分类:
