Invention Grant
US08637039B2 Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof
有权
插入腺苷酸环化酶蛋白或其片段的携带人乳头状瘤病毒表位的重组蛋白质的治疗用途
- Patent Title: Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof
- Patent Title (中): 插入腺苷酸环化酶蛋白或其片段的携带人乳头状瘤病毒表位的重组蛋白质的治疗用途
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Application No.: US12977754Application Date: 2010-12-23
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Publication No.: US08637039B2Publication Date: 2014-01-28
- Inventor: Xavier-Edmond-Edouard Preville , Claude Leclerc , Daniel Ladant , Benedikt Timmerman
- Applicant: Xavier-Edmond-Edouard Preville , Claude Leclerc , Daniel Ladant , Benedikt Timmerman
- Applicant Address: FR Paris FR Paris FR Paris FR Labege-Innopole
- Assignee: Institut Pasteur,Institut National de la Sante et de la Recherche Medicale,Centre National de la Recherche Scientifique,Genticel
- Current Assignee: Institut Pasteur,Institut National de la Sante et de la Recherche Medicale,Centre National de la Recherche Scientifique,Genticel
- Current Assignee Address: FR Paris FR Paris FR Paris FR Labege-Innopole
- Agency: Law Office of Salvatore Arrigo and Scott Lee, LLP
- Priority: EP04290741 20040318
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/295 ; C07K14/235 ; C07K14/025
Abstract:
The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
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