Invention Grant
US08637262B2 Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
失效
血管内皮生长因子C（VEGF-C）蛋白和基因，突变体及其用途
- Patent Title: Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
- Patent Title (中): 血管内皮生长因子C（VEGF-C）蛋白和基因，突变体及其用途
-
Application No.: US13646563Application Date: 2012-10-05
-
Publication No.: US08637262B2Publication Date: 2014-01-28
- Inventor: Kari Alitalo , Vladimir Joukov
- Applicant: Vegenics PTY Limited
- Applicant Address: AU South Yarra
- Assignee: Vegenics Pty Limited
- Current Assignee: Vegenics Pty Limited
- Current Assignee Address: AU South Yarra
- Agent Jeanne M. Brashear
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C07K16/00
Abstract:
Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides. Methods of inhibiting endothelial cell proliferation are also provided.
Public/Granted literature
- US20130224766A1 VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) PROTEIN AND GENE, MUTANTS THEREOF, AND USES THEREOF Public/Granted day:2013-08-29
Information query
IPC分类:
