Invention Grant
- Patent Title: High fidelity restriction endonucleases
- Patent Title (中): 高保真限制性内切核酸酶
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Application No.: US13022561Application Date: 2011-02-07
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Publication No.: US08637291B2Publication Date: 2014-01-28
- Inventor: Zhenyu Zhu , Aine Quimby , Shengxi Guan , Dapeng Sun , Yishu Huang , Xuhui Lai , Siu-hong Chan , Xianghui Li , Shuang-Yong Xu , Chunhua Zhang
- Applicant: Zhenyu Zhu , Aine Quimby , Shengxi Guan , Dapeng Sun , Yishu Huang , Xuhui Lai , Siu-hong Chan , Xianghui Li , Shuang-Yong Xu , Chunhua Zhang
- Applicant Address: US MA Ipswich
- Assignee: New England Biolabs, Inc.
- Current Assignee: New England Biolabs, Inc.
- Current Assignee Address: US MA Ipswich
- Agency: New England Biolabs, Inc.
- Agent Harriet M. Strimpel
- Main IPC: C12N9/22
- IPC: C12N9/22
Abstract:
Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.
Public/Granted literature
- US20110151450A1 High Fidelity Restriction Endonucleases Public/Granted day:2011-06-23
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