Invention Grant
US08637301B2 Microfluidic solution for high-throughput, droplet-based single molecule analysis with low reagent consumption
有权
微流控解决方案，用于高通量，基于液滴的单分子分析，低试剂消耗
- Patent Title: Microfluidic solution for high-throughput, droplet-based single molecule analysis with low reagent consumption
- Patent Title (中): 微流控解决方案，用于高通量，基于液滴的单分子分析，低试剂消耗
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Application No.: US13147742Application Date: 2010-03-02
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Publication No.: US08637301B2Publication Date: 2014-01-28
- Inventor: Jeff Tza-Huei Wang , Kelvin J. Liu , Christopher M. Puleo , Tushar D. Rane
- Applicant: Jeff Tza-Huei Wang , Kelvin J. Liu , Christopher M. Puleo , Tushar D. Rane
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Venable LLP
- Agent Henry J. Daley
- International Application: PCT/US2010/025933 WO 20100302
- International Announcement: WO2010/101926 WO 20100910
- Main IPC: C12M1/00
- IPC: C12M1/00 ; C12M1/36 ; C12M1/34 ; G01N15/06 ; G01N21/64 ; G02B21/06
Abstract:
A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region.
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