Invention Grant
US08637306B2 Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
有权
使用化学反应性非天然氨基酸生产载体 - 肽缀合物
- Patent Title: Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
- Patent Title (中): 使用化学反应性非天然氨基酸生产载体 - 肽缀合物
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Application No.: US12653274Application Date: 2009-12-09
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Publication No.: US08637306B2Publication Date: 2014-01-28
- Inventor: Travis Young , Peter G. Schultz
- Applicant: Travis Young , Peter G. Schultz
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Quine Intellectual Property Law Group, P.C.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K1/00 ; C12P1/00 ; C12N15/09
Abstract:
Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided.
Public/Granted literature
- US20100297693A1 Production of carrier-peptide conjugates using chemically reactive unnatural amino acids Public/Granted day:2010-11-25
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