Invention Grant
US08637476B2 Apoptotic cell-mediated transfection of mammalian cells with interfering RNA
有权
凋亡细胞介导的用干扰RNA转染哺乳动物细胞
- Patent Title: Apoptotic cell-mediated transfection of mammalian cells with interfering RNA
- Patent Title (中): 凋亡细胞介导的用干扰RNA转染哺乳动物细胞
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Application No.: US12440912Application Date: 2007-09-28
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Publication No.: US08637476B2Publication Date: 2014-01-28
- Inventor: Fengchun Li , Alan P. Escher
- Applicant: Fengchun Li , Alan P. Escher
- Applicant Address: US CA Loma Linda
- Assignee: Loma Linda University
- Current Assignee: Loma Linda University
- Current Assignee Address: US CA Loma Linda
- Agency: McDermott Will & Emery LLP
- International Application: PCT/US2007/079876 WO 20070928
- International Announcement: WO2008/039980 WO 20080403
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
Mammalian host cells for use in a cell-mediated tranfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of downregulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs downregulates the expression of the target gene in living cells.
Public/Granted literature
- US20100068813A1 APOPTOTIC CELL-MEDIATED TRANSFECTION OF MAMMALIAN CELLS WITH INTERFERING RNA Public/Granted day:2010-03-18
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