Invention Grant
US08637547B2 Compounds which inhibit members of the histone deacetylase family of enzymes and their use in the treatment of cell proliferative diseases
有权
抑制酶的组蛋白脱乙酰酶家族成员的化合物及其在治疗细胞增殖性疾病中的用途
- Patent Title: Compounds which inhibit members of the histone deacetylase family of enzymes and their use in the treatment of cell proliferative diseases
- Patent Title (中): 抑制酶的组蛋白脱乙酰酶家族成员的化合物及其在治疗细胞增殖性疾病中的用途
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Application No.: US12443096Application Date: 2007-09-14
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Publication No.: US08637547B2Publication Date: 2014-01-28
- Inventor: Alan Hornsby Davidson , David Charles Festus Moffat , Francesca Ann Day , Alistair David Graham Donald
- Applicant: Alan Hornsby Davidson , David Charles Festus Moffat , Francesca Ann Day , Alistair David Graham Donald
- Applicant Address: GB Oxfordshire
- Assignee: Chroma Therapeutics Ltd.
- Current Assignee: Chroma Therapeutics Ltd.
- Current Assignee Address: GB Oxfordshire
- Priority: GB0619753 20061006
- International Application: PCT/GB2007/003504 WO 20070914
- International Announcement: WO2008/040934 WO 20080410
- Main IPC: A61K31/4965
- IPC: A61K31/4965 ; C07C261/00 ; C07D211/56 ; C07D211/92 ; C07D295/00 ; A01N37/18 ; A61K31/445
Abstract:
Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent ═C— or ═N—; W is a divalent radical —CH═CH— or CH2CH2—; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L1, and X1 are as defined in the claims.
Public/Granted literature
- US20100010010A1 HDAC INHIBITORS Public/Granted day:2010-01-14
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