Invention Grant
US08637639B2 Method and composition for crystallizing G protein-coupled receptors
有权
用于结晶G蛋白偶联受体的方法和组合物
- Patent Title: Method and composition for crystallizing G protein-coupled receptors
- Patent Title (中): 用于结晶G蛋白偶联受体的方法和组合物
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Application No.: US13436709Application Date: 2012-03-30
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Publication No.: US08637639B2Publication Date: 2014-01-28
- Inventor: Brian Kobilka , Daniel Rosenbaum
- Applicant: Brian Kobilka , Daniel Rosenbaum
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent James S. Keddie
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C07K19/00 ; C12N15/62
Abstract:
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.
Public/Granted literature
- US20130197192A1 Method and Composition for Crystallizing G Protein-Coupled Receptors Public/Granted day:2013-08-01
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