Invention Grant
- Patent Title: Siderophore-mediated iron uptake in bacterial infection
- Patent Title (中): 细菌感染中铁载体介导的铁摄取
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Application No.: US13059723Application Date: 2009-08-14
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Publication No.: US08637657B2Publication Date: 2014-01-28
- Inventor: David E. Heinrichs , Federico Beasley , Enríque Vines , Johnson Cheung
- Applicant: David E. Heinrichs , Federico Beasley , Enríque Vines , Johnson Cheung
- International Application: PCT/CA2009/001143 WO 20090814
- International Announcement: WO2010/020036 WO 20100225
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/85 ; C12N9/00 ; C07H21/02
Abstract:
The present invention relates to methods of inhibiting S. aureus comprising inhibiting siderophore-mediated iron uptake, for example, staphyloferrm-mediated iron uptake Such methods of inhibiting S. aureus include the inhibition of staphyloferrm A- and staphyloferrm B-mediated uptake either by inhibiting expression or activity of staphyloferrm A and B or by inhibiting transport of staphyloferrm A and B The methods as provided would be useful for treating S. aureus infection.
Public/Granted literature
- US20110245321A1 SIDEROPHORE-MEDIATED IRON UPTAKE IN BACTERIAL INFECTION Public/Granted day:2011-10-06
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