Invention Grant
US08637666B2 Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
失效
制备可用作蛋白激酶抑制剂的嘧啶衍生物的方法
- Patent Title: Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
- Patent Title (中): 制备可用作蛋白激酶抑制剂的嘧啶衍生物的方法
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Application No.: US13424736Application Date: 2012-03-20
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Publication No.: US08637666B2Publication Date: 2014-01-28
- Inventor: Jean-Damien Charrier , Steven Durrant , David Kay
- Applicant: Jean-Damien Charrier , Steven Durrant , David Kay
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agent Rory C. Stewart
- Main IPC: C07D487/12
- IPC: C07D487/12
Abstract:
A method of preparing a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims, comprises the step of: a) cyclizing a compound represented by Structural Formula A: under suitable reductive cyclization conditions to form a compound represented by Structural Formula B: wherein R10 is LG1 or —X1R1, and -LG1 is a suitable leaving group; and b) optionally, when R10 of Structural Formula (B) is LG1, further comprising the step of replacing the -LG1 of Structural Formula (B) with —X1R1 to form the compound represented by Structural Formula (I).
Public/Granted literature
- US20120178926A1 METHODS FOR PREPARING PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS Public/Granted day:2012-07-12
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