Invention Grant
- Patent Title: Production method for adefovir dipivoxil
- Patent Title (中): 阿德福韦酯的生产方法
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Application No.: US13119538Application Date: 2009-09-17
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Publication No.: US08637669B2Publication Date: 2014-01-28
- Inventor: Kwang Do Choi , Yong Tack Lee , Myeong Sik Yoon , Hye Suk Hong , Il Hwan Cho , Si Beum Lee , Seong Cheol Bang , Da Won Oh , Min Kyoung Lee
- Applicant: Kwang Do Choi , Yong Tack Lee , Myeong Sik Yoon , Hye Suk Hong , Il Hwan Cho , Si Beum Lee , Seong Cheol Bang , Da Won Oh , Min Kyoung Lee
- Applicant Address: KR Seoul
- Assignee: CJ Cheiljedang Corporation
- Current Assignee: CJ Cheiljedang Corporation
- Current Assignee Address: KR Seoul
- Agency: Seed IP Law Group PLLC
- Priority: KR10-2008-0091390 20080918; KR10-2009-0001394 20090108
- International Application: PCT/KR2009/005305 WO 20090917
- International Announcement: WO2010/032974 WO 20100325
- Main IPC: C07F9/6561
- IPC: C07F9/6561 ; C07D473/34 ; C07F9/28 ; C07F9/40 ; A61K31/675 ; C07F9/00
Abstract:
The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50° C. under the presence of dimethylsulfoxide and triethylamine solvents.
Public/Granted literature
- US20110207930A1 IMPROVED PRODUCTION METHOD FOR ADEFOVIR DIPIVOXIL Public/Granted day:2011-08-25
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