Invention Grant
- Patent Title: Dual-acting benzoimidazole antihypertensive agents
- Patent Title (中): 双效苯并咪唑抗高血压药
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Application No.: US12156695Application Date: 2008-06-04
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Publication No.: US08637676B2Publication Date: 2014-01-28
- Inventor: Paul Allegretti , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant: Paul Allegretti , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/4184
- IPC: A61K31/4184 ; C07D235/08
Abstract:
The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20080318951A1 Dual-acting benzoimidazole antihypertensive agents Public/Granted day:2008-12-25
Information query
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