Invention Grant
US08637681B2 Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof
失效
吡咯基取代的二氢吲哚-2-酮衍生物,其制备方法和用途
- Patent Title: Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof
- Patent Title (中): 吡咯基取代的二氢吲哚-2-酮衍生物,其制备方法和用途
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Application No.: US13702956Application Date: 2011-03-31
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Publication No.: US08637681B2Publication Date: 2014-01-28
- Inventor: Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
- Applicant: Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
- Applicant Address: CN Jinan, Shandong
- Assignee: Qilu Pharmaceutical Co., Ltd.
- Current Assignee: Qilu Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Jinan, Shandong
- Agency: Seed IP Law Group PLLC
- Priority: CN201010194609 20100608
- International Application: PCT/CN2011/000561 WO 20110331
- International Announcement: WO2011/153814 WO 20111215
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D403/14 ; C07D413/14 ; C07D411/06 ; A61K31/403 ; A61K31/497 ; A61K31/535

Abstract:
Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human).
Public/Granted literature
- US20130158030A1 PYRROLYL SUBSTITUTED DIHYDROINDOL-2-ONE DERIVATIVES, PREPARATION METHODS AND USES THEREOF Public/Granted day:2013-06-20
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