Invention Grant
US08637692B2 Process for preparation of 1,2-diamino-cyclohexane-platinum (II) complexes
失效
1,2-二氨基 - 环己烷 - 铂（II）配合物的制备方法
- Patent Title: Process for preparation of 1,2-diamino-cyclohexane-platinum (II) complexes
- Patent Title (中): 1,2-二氨基 - 环己烷 - 铂（II）配合物的制备方法
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Application No.: US13376791Application Date: 2010-06-22
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Publication No.: US08637692B2Publication Date: 2014-01-28
- Inventor: Néstor Pablo Cid , Miguel Julio Novas , Agustin Alfredo Tomei
- Applicant: Néstor Pablo Cid , Miguel Julio Novas , Agustin Alfredo Tomei
- Applicant Address: DE Hanau-Wolfgang
- Assignee: Umicore AG & Co. KG
- Current Assignee: Umicore AG & Co. KG
- Current Assignee Address: DE Hanau-Wolfgang
- Agency: Smith, Gambrell & Russell, LLP
- Priority: EP09008348 20090626
- International Application: PCT/EP2010/003753 WO 20100622
- International Announcement: WO2010/149337 WO 20101229
- Main IPC: C07F15/00
- IPC: C07F15/00
Abstract:
The present invention is directed to a manufacturing process for 1,2-diamino-cyclohexane-platinum(II) complexes, specifically to a manufacturing process for oxaliplatin.The process is straightforward, economical and applicable to industrial production. It comprises the reaction of (DACH)PtCl2 with silver sulfate (Ag2SO4) and the subsequent reaction of the resulting Pt sulfate complex (DACH)Pt(aq)2SO4 with barium oxalate (BaC2O4) or an equimolar mixture of barium hydroxide and oxalic acid to yield oxaliplatin in high purity with a low silver and low nitrate content.
Public/Granted literature
- US20130131368A1 PROCESS FOR PREPARATION OF 1,2-DIAMINO-CYCLOHEXANE-PLATINUM (II) COMPLEXES Public/Granted day:2013-05-23
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