A radiation detection system can include optical fibers and a material disposed between the optical fibers. In an embodiment, the material can include a fluid, such as a gas, a liquid, or a non-Newtonian fluid. In another embodiment, the material can include an optical coupling material. In a particular embodiment, the optical coupling material can include a silicone rubber. In still another embodiment, the optical coupling material has a refractive index less than 1.50. In still another embodiment, the radiation detection system can have a greater signal:noise ratio, a light collection efficiency, or both as compared to a conventional radiation detection system. Corresponding methods of use are disclosed that can provide better discrimination between neutrons and gamma radiation.