Aspects of a method and system for sleep mode signaling for a multi-standard system with Bluetooth are provided. In this regard, a first communication system that communicates utilizing TDM may generate a synchronization signal that is communicatively coupled to a second communication system that communicates utilizing TDM. The first communication system may determine one or more timeslots during which it may be inactive. The first communication system may control, based on the determination, an amount of time that the synchronization signal is in one or more states. The second communication system may receive the synchronization signal from the first communication system. The second communication system may determine timeslots during which the first communication system may be inactive based on an amount of time that the synchronization signal is in one or more states. The second communication system may transmit and/or receive at times that are scheduled based on the determination.