A single sensing probe comprising multiple, spatially separate, sensing sites is utilized to sense neural activity. The sensing probe includes multiple conductors each with multiple sensing sites in a fixed geometric arrangement. The sensing probe is configured to comprise multiple combined sensing sites in polytrode configuration. By appropriately combining the wire groupings at each combined sensing site, activity sensed from a single wire with multiple sensing sites, can be coupled with other wires to unmix signals from the spatially separate sites and leverage the power of combinatorics to maximize total recording bandwidth and single neuron/unit yield per wire and per probe.