Systems and methods are provided for diagnosis of and early treatment adoption for asymptomatic diseases. In one embodiment, an examination system is provided including an input device for entering patient data, a computer including a medium for storing entered data, and a feedback module for providing feedback to an examined patient based on the data entered. A method of using the examination system is also provided in which feedback is provided directly to the patient concurrently with the measurement or other acquisition of a significant data point. Feedback is also provided at the conclusion of the examination in the form of a report, treatment plan, or customized educational materials. In a further embodiment, the patient is an active participant in the examination, recording data points themselves via the input device.