Provided are a method, system, and article of manufacture for authenticating a processing system accessing a resource. An association of processing system identifiers with resources, including a first and second resources, is maintained. A request from a requesting processing system in a host is received for use of a first resource that provides access to a second resource, wherein the request is generated by processing system software and wherein the request further includes a submitted processing system identifier included in the request by host hardware in the host. A determination is made as to whether the submitted processing system identifier is one of the processing system identifiers associated with the first and second resources. The requesting processing system is provided access to the first resource that the processing system uses to access the second resource.