A multipurpose site guard for use at all peripheral and central venipuncture infusion sites, sensitive areas, and for pediatric and adult patients. The guard is a hollow plastic member with a base and a sidewall that forms a cover over the site. Improvements to this invention include holding the guard in place with a fabric connector having closure means, cushioning the guard's base with a soft material, and a hole disposed in the hollow member for providing access to the site.