A medicine filling device for filling empty vials of different shapes and sizes with medicine without having to replace any members or having to perform any special operations is disclosed. More specifically, the medicine filling device is provided with a first transfer means to transfer an empty vial B stored within a stocker while the vial B is positioned on a side, a vial lifter (second transfer means) to hold the transferred vial B in an upright position and to move said vial B towards a medicine filling unit, and a vial orientation detection means to detect the orientation of the vial B which was removed from the stocker by the first transfer means. The first transfer means is provided with a reversal mechanism and the vial B is supplied to the vial lifter from the first transfer means while the bottom of the vial B faces a vial guiding means.