Invention Grant
US08642007B2 Method and compound for treatment of cancer using phosphorous-32 labeled DNA
有权
使用磷32标记的DNA治疗癌症的方法和化合物
- Patent Title: Method and compound for treatment of cancer using phosphorous-32 labeled DNA
- Patent Title (中): 使用磷32标记的DNA治疗癌症的方法和化合物
-
Application No.: US12886127Application Date: 2010-09-20
-
Publication No.: US08642007B2Publication Date: 2014-02-04
- Inventor: Yanping Kong , Jinhong Liu
- Applicant: Yanping Kong , Jinhong Liu
- Agency: Loginov & Sicard
- Agent William A. Loginov
- Main IPC: A61K51/00
- IPC: A61K51/00 ; C07H21/04 ; A61P35/00

Abstract:
This invention provides a combination of a gene and isotope therapy that is applied to a cancerous tissue to selectively kill that associated cancer cells with minimal negative effects on surrounding non-cancerous cells. Functionally, the specific DNA fragments with labeled isotope are able to bind the tumor cells DNA through recombination, and then the isotope kills the tumor cells. A gene is employed as a carrier to deliver the P-32 which can kill cancer cells through radioactive emission. Unlike traditional gene therapy, which employs a gene to express a protein, which can suppress the cancer cell growth or increase the sensitivity for radiation therapy or chemotherapy, the illustrative embodiment actually binds the radioactive substance via a gene. The illustrative embodiment produces the compound/agent containing a gene (DNA fragment) and P-32 through use of conventional P-32 labeling techniques such as those employed in molecular biology experiments (for example experiments used to test gene expression and gene amplification potency). In the illustrative embodiment, however, the same P-32 labeled DNA is employed directly for cancer treatment through a novel medical treatment method. Appropriate doses are provided to patients as part of a medical treatment method.
Public/Granted literature
- US20120070373A1 METHOD AND COMPOUND FOR TREATMENT OF CANCER USING PHOSPHOROUS-32 LABELED DNA Public/Granted day:2012-03-22
Information query