Invention Grant
- Patent Title: Molecular probe for imaging of pancreatic islets and use of the same
- Patent Title (中): 胰岛成像用分子探针及其用途
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Application No.: US12872837Application Date: 2010-08-31
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Publication No.: US08642008B2Publication Date: 2014-02-04
- Inventor: Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- Applicant: Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- Applicant Address: JP Kyoto JP Kyoto
- Assignee: Kyoto University,ARKRAY, Inc.
- Current Assignee: Kyoto University,ARKRAY, Inc.
- Current Assignee Address: JP Kyoto JP Kyoto
- Agency: Morgan, Lewis & Bockius LLP
- Priority: JP2009-204769 20090904; WOPCT/JP2010/054450 20100316
- Main IPC: A61K51/08
- IPC: A61K51/08

Abstract:
To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides: Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (5) B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (9) where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring, wherein A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R1 represents a substituent that contains radioactive iodine, R2 represents either a hydrogen atom or a substituent different from that represented by R1, and R3 represents any one of a bond, a methylene group, and an oxymethylene group.
Public/Granted literature
- US20110059483A1 Molecular Probe for Imaging of Pancreatic Islets and Use of the Same Public/Granted day:2011-03-10
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