Invention Grant
US08642258B2 Immunogenical complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica
有权
由纳米结构介孔二氧化硅包封的疫苗抗原形成的免疫复合物
- Patent Title: Immunogenical complex formed by vaccinal antigens encapsulated by nanostructured mesoporous silica
- Patent Title (中): 由纳米结构介孔二氧化硅包封的疫苗抗原形成的免疫复合物
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Application No.: US12066489Application Date: 2006-09-12
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Publication No.: US08642258B2Publication Date: 2014-02-04
- Inventor: Ogari Pacheco , Osvaldo Augusto Sant'Anna , Lucildes Mercure , Jivaldo Matos , Márcia Fantini
- Applicant: Ogari Pacheco , Osvaldo Augusto Sant'Anna , Lucildes Mercure , Jivaldo Matos , Márcia Fantini
- Applicant Address: BR Itapira BR Sao Paulo
- Assignee: Cristalia Produtos Quimicos Farmaceuticos Ltda.,Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-Fapesp
- Current Assignee: Cristalia Produtos Quimicos Farmaceuticos Ltda.,Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-Fapesp
- Current Assignee Address: BR Itapira BR Sao Paulo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: BR0503817 20050912
- International Application: PCT/BR2006/000182 WO 20060912
- International Announcement: WO2007/030901 WO 20070322
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; A61K39/00 ; A61K39/295 ; A61K39/116

Abstract:
The present invention relates to a product named “immunogenical complex”, which comprises an adjuvant characterized by solid particles of highly ordinated nanostructured mesoporous silica, preferably, SBA-15 Silica, and vaccinal antigens of several natures, encapsulated in the referred to adjuvants. The immunogenical complex of the present invention allows the presentation of the antigens that compose it to lymphocytes, in a safe, gradual and extended way, which leads to a more efficient immunological memory, increases the immunogenicity of the antigen and improves the production of antibodies. This ensures an efficient immunological protection with fewer amounts of antigens and/or less repetitions of vaccinal doses. In addition, the characteristics of the immunogenical complex of the present invention promotes effective immunity induction, homogeneous in “god and bad respondent” individuals.
Public/Granted literature
- US20080286371A1 Immunogenical Complex Formed by Vaccinal Antigens Encapsulated by Nanostructured Mesoporous Silica Public/Granted day:2008-11-20
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