Invention Grant
- Patent Title: Screening assay for agents that alter target of rapamycin activity
- Patent Title (中): 筛选雷帕霉素活性靶标的药物
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Application No.: US11441650Application Date: 2006-05-26
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Publication No.: US08642283B2Publication Date: 2014-02-04
- Inventor: Robert T. Abraham
- Applicant: Robert T. Abraham
- Applicant Address: US CA La Jolla
- Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Pabst Patent Group LLP
- Main IPC: C12Q1/42
- IPC: C12Q1/42 ; C12Q1/68 ; G01N33/573 ; G01N33/53
Abstract:
The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate proteins whose amino acid sequence contains the Ser/Thr motif recognized by TOR. Naturally occurring TOR which may be used in the methods of the invention include TOR isolated from a variety of species, particularly mammalian tissues.
Public/Granted literature
- US20060216776A1 Screening assay for agents that alter target of rapamycin activity Public/Granted day:2006-09-28
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