Invention Grant
US08642314B2 Optimization of expression of parvoviral rep and cap proteins in insect cells
有权
优化昆虫细胞中细小病毒代谢和帽蛋白的表达
- Patent Title: Optimization of expression of parvoviral rep and cap proteins in insect cells
- Patent Title (中): 优化昆虫细胞中细小病毒代谢和帽蛋白的表达
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Application No.: US12918460Application Date: 2009-02-19
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Publication No.: US08642314B2Publication Date: 2014-02-04
- Inventor: Andrew Christian Bakker , Wilhelmus Theodorus Johannes Maria Christiaan Hermens , Yvet Noordman
- Applicant: Andrew Christian Bakker , Wilhelmus Theodorus Johannes Maria Christiaan Hermens , Yvet Noordman
- Applicant Address: NL
- Assignee: Amsterdam Molecular Therapeutics (AMT) B.V.
- Current Assignee: Amsterdam Molecular Therapeutics (AMT) B.V.
- Current Assignee Address: NL
- Agency: Browdy and Neimark, PLLC
- Priority: EP08151634 20080219
- International Application: PCT/NL2009/050076 WO 20090219
- International Announcement: WO2009/104964 WO 20090827
- Main IPC: C12N7/00
- IPC: C12N7/00 ; C12N7/01
Abstract:
The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors.
Public/Granted literature
- US20110136227A1 OPTIMISATION OF EXPRESSION OF PARVOVIRAL REP AND CAP PROTEINS IN INSECT CELLS Public/Granted day:2011-06-09
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