Invention Grant
US08642357B2 Semaphorin 7A plays a critical role in TGF-β1-induced pulmonary fibrosis and alveolar destruction
有权
信号素7A在TGF-β1诱导的肺纤维化和肺泡破坏中起关键作用
- Patent Title: Semaphorin 7A plays a critical role in TGF-β1-induced pulmonary fibrosis and alveolar destruction
- Patent Title (中): 信号素7A在TGF-β1诱导的肺纤维化和肺泡破坏中起关键作用
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Application No.: US12604192Application Date: 2009-10-22
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Publication No.: US08642357B2Publication Date: 2014-02-04
- Inventor: Jack A. Elias , Chun Geun Lee
- Applicant: Jack A. Elias , Chun Geun Lee
- Applicant Address: US CT New Haven
- Assignee: Yale University
- Current Assignee: Yale University
- Current Assignee Address: US CT New Haven
- Agency: Saul Ewing LLP
- Agent Kathryn Doyle
- Main IPC: G01N33/53
- IPC: G01N33/53 ; A61K39/395 ; C12Q1/68 ; C12N15/11 ; C12N15/113 ; A61K38/00

Abstract:
The present invention provides methods of treating a subject diagnosed with, or at risk for developing, pathogenic fibrosis, particularly pulmonary fibrosis. The method of the invention comprises administering to the subject a compound or composition which inhibits semaphorin (SEMA) 7A, SEMA 7A receptors, or downstream effectors. A SEMA 7A inhibitor comprises an antibody, a soluble SEMA 7A receptor, an siRNA, a ribozyme, an antisense, an aptamer, a peptidomimetic, a small molecule, a soluble receptor, or any combinations thereof.
Public/Granted literature
- US20100104570A1 Semaphorin 7A Plays a Critical Role in TGF-Beta1-Induced Pulmonary Fibrosis and Alveolar Destruction Public/Granted day:2010-04-29
Information query
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