Invention Grant
- Patent Title: Short fatty acid tail polymyxin derivatives and uses thereof
- Patent Title (中): 短脂肪酸尾多粘菌素衍生物及其用途
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Application No.: US13462389Application Date: 2012-05-02
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Publication No.: US08642535B2Publication Date: 2014-02-04
- Inventor: Martti Sakari Vaara , Timo Ilmari Vaara
- Applicant: Martti Sakari Vaara , Timo Ilmari Vaara
- Applicant Address: FI Helsinki
- Assignee: Northern Antibiotics Ltd.
- Current Assignee: Northern Antibiotics Ltd.
- Current Assignee Address: FI Helsinki
- Agency: Lathrop & Gage LLP
- Main IPC: C07K7/62
- IPC: C07K7/62 ; A61K38/12
Abstract:
The present invention relates to a polymyxin derivative wherein the derivative has a total of three positive charges at physiological pH and wherein the terminal moiety (D) of the derivative comprises a total of 1 to 5 carbon atoms. The invention also relates to a method of treating a subject for a gram-negative bacterial infection by administering a polymyxin derivative of the invention in combination with a second antibacterial agent. Finally, the invention relates to a process for preparing such polymyxin derivatives.
Public/Granted literature
- US20120283176A1 SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF Public/Granted day:2012-11-08
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