Invention Grant
- Patent Title: Methods for expansion of hematopoietic stem and progenitor cells
- Patent Title (中): 扩大造血干细胞和祖细胞的方法
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Application No.: US13145706Application Date: 2010-01-21
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Publication No.: US08642569B2Publication Date: 2014-02-04
- Inventor: David Scadden , Jonas Larsson
- Applicant: David Scadden , Jonas Larsson
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick
- International Application: PCT/US2010/021638 WO 20100121
- International Announcement: WO2010/085555 WO 20100729
- Main IPC: C12N15/113
- IPC: C12N15/113
Abstract:
Described herein are methods and compositions for expanding hematopoietic stem and progenitor cells (HSPC) ex vivo and in vivo, and methods and compositions for transplanting HSPCs and treatment of anemia in a human subject. HSPCs are expanded in the presence of an inhibitor of serine threonine kinase 38 (STK38), wherein said inhibitor is preferably an RNAi agent.
Public/Granted literature
- US20110305675A1 METHODS FOR EXPANSION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS Public/Granted day:2011-12-15
Information query
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