Invention Grant
- Patent Title: Alkynylpyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
- Patent Title (中): 炔基嘧啶及其盐，包含其的药物组合物，其制备方法及其用途
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Application No.: US12142279Application Date: 2008-06-19
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Publication No.: US08642611B2Publication Date: 2014-02-04
- Inventor: Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Thierauch , Philip Lienau , Ulf Boemer
- Applicant: Ingo Hartung , Ulrich Bothe , Georg Kettschau , Ulrich Luecking , Anne Mengel , Martin Krueger , Karl Thierauch , Philip Lienau , Ulf Boemer
- Applicant Address: DE Monheim
- Assignee: Bayer Intellectual Property GmbH
- Current Assignee: Bayer Intellectual Property GmbH
- Current Assignee Address: DE Monheim
- Priority: EP07090125 20070620
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/505 ; C07D401/00 ; C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D411/00 ; C07D413/00 ; C07D417/00 ; C07D419/00 ; C07D239/02
Abstract:
The invention relates to alkynylpyrimidines according to the general formula (I): in which A, R1, R2, R3, R4, R5, and R6 are as defined in the claims, and salts, N-oxides, metabolites, solvates, tautomers and prodrugs thereof, to pharmaceutical compositions comprising said alkynylpyrimidines, to methods of preparing said alkynylpyrimidines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 and VEGFR2 signalling.
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