Invention Grant
- Patent Title: 1-phenylpyrrole derivatives
- Patent Title (中): 1-苯基吡咯衍生物
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Application No.: US13122239Application Date: 2009-10-07
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Publication No.: US08642640B2Publication Date: 2014-02-04
- Inventor: John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Hiroyuki Tsuruoka , Kazumasa Aoki , Masatoshi Honzumi , Yusuke Asoh , Keiji Saito , Tsuyoshi Homma
- Applicant: John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Hiroyuki Tsuruoka , Kazumasa Aoki , Masatoshi Honzumi , Yusuke Asoh , Keiji Saito , Tsuyoshi Homma
- Applicant Address: US CA South San Francisco JP Tokyo
- Assignee: Exelixis, Inc.,Daiichi Sankyo Company, Limited
- Current Assignee: Exelixis, Inc.,Daiichi Sankyo Company, Limited
- Current Assignee Address: US CA South San Francisco JP Tokyo
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- International Application: PCT/US2009/059852 WO 20091007
- International Announcement: WO2010/042626 WO 20100415
- Main IPC: A61K31/40
- IPC: A61K31/40 ; C07D207/08

Abstract:
The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a hydroxy-C1-C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like, —R5 represents a sulfamoyl group or a C1-C3 alkylsulfonyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.
Public/Granted literature
- US20110263544A1 1-Phenylpyrrole Derivatives Public/Granted day:2011-10-27
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