Invention Grant
- Patent Title: Photolabile dinitroindolinyl based compounds
- Patent Title (中): 光不稳定二硝基吲哚啉基化合物
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Application No.: US12520924Application Date: 2008-01-29
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Publication No.: US08642785B2Publication Date: 2014-02-04
- Inventor: Graham Ellis-Davies
- Applicant: Graham Ellis-Davies
- Applicant Address: US PA Philadelphia
- Assignee: Philadelphia Health & Education Corporation
- Current Assignee: Philadelphia Health & Education Corporation
- Current Assignee Address: US PA Philadelphia
- Agency: Mendelsohn, Drucker & Dunleavy, P.C.
- International Application: PCT/US2008/052331 WO 20080129
- International Announcement: WO2008/094922 WO 20080807
- Main IPC: C07D209/04
- IPC: C07D209/04

Abstract:
The present invention relates to photolabile or photoreleasable compounds including a caging moiety linked to an effector moiety, wherein the compounds are capable of releasing the effector moiety on irradiation, typically by flash irradiation with UV light. These compounds are particularly suitable for focal 2-photon uncaging The photoreleasable compounds can be used to deliver effector moieties such as carboxylic acids, preferably, neuroactive amino acids to sites where their activity is required. In preferred embodiments of the invention, the caging moiety is based on 4-carboxymethoxy-5,7-dinitroinlinyl and derivatives thereof.
Public/Granted literature
- US20100096252A1 PHOTOLABILE DINITROINDOLINYL BASED COMPOUNDS Public/Granted day:2010-04-22
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