The present invention provides a self-driven synchronous rectification boost converter having high step-up ratio. The self-driven synchronous rectification boost converter having high step-up ratio has a first switch receiving a pulse driving signal, a first winding, a second winding and a synchronous rectification circuit constructed by an auxiliary winding and a second switch. The first winding inducts a reverse voltage when the first switch is repeatedly switched on and off. The reverse voltage then is raised via the second winding, and the auxiliary winding cooperates with a switch circuit to switch on/off the second switch according to an inducted voltage, so as to achieve an object of synchronous rectification. Under a condition of outputting high current, the present invention can greatly reduce power-consumption of rectifying and enhance efficiency.