A hybrid simulation model includes a real model, a bus interface and an acceleration model. The real model simulates a group of instructions. The acceleration model includes a trace generation unit, a trace replay unit, a selection unit, a snapshot generation and load unit and a virtual breakpoint control unit. The trace generation unit records at least one trace file of the real model in a first simulation. The trace replay unit reads and accordingly accesses the at least one trace file. The selection unit dynamically switches to perform a real simulation or a trace simulation. The snapshot generation and load unit generates at least one status snapshot file and loads the at least one status snapshot file to the real model in repeated simulations. The virtual breakpoint control unit controls the selection unit to switch between the trace simulation and the real simulation according to a virtual breakpoint.