Systems and methods for multi-dimensional, value-based clinical care path decision support are provided. A system includes a care decision subsystem to receive a patient problem and at least one clinical patient attribute, to identify a plurality of patient care path options for evaluation by the patient and a provider, and to generate a mashup of patient-specific criteria including clinical efficacy, cost, and access associated with each of the plurality of patient care path options. Each of the plurality of patient care path options can be utilized in an evaluation with respect to an objective associated with the patient problem. A user interface displays the plurality of patient care path options and associated mashup of patient-specific criteria to facilitate a data-driven selection of at least one of the plurality of patient care path options based on comparative efficacy, cost, and access tailored to the patient.